It’s a procedure whereby an embryo is grown in a lab for 4-6 days following conception before being implanted in the womb. As a consequence of being formed for so many days, the embryo gains a large number of cells. The embryos that have been cultivated for 4-6 days are far more advanced than those that have just been developed for three days. Blastocysts are the name for these embryos.
The embryo that endures for 4-6 days has a better chance of producing fruit. This allows embryologists to choose from higher mature embryos that have a better chance of implantation.
Blastocyst Culture and Transfer Benefits
It reduces the likelihood of multiple pregnancies greatly. This approach also has a greater pregnancy and implantation rate of success since it is easier to identify robust embryos after they have developed for 4-6 days, thus only the competent embryos are sent to the uterus. The most essential benefit of blastocyst transfer is the synchronization of the embryos with the uterine endometrium and the choice of the top-quality embryos with a high implantation potential.
IVF perks of blastocyst transfer
- Blastocyst culture necessitates ideal lab conditions. Around 45 percent of fertilized eggs make it to the blastocyst stage.
- Because only the most capable embryos develop into blastocysts, enabling embryos to develop and grow in the laboratory until they attain the blastocyst stage permits the most proficient embryo/s to be selected for embryo transfer.
- In a natural gestation, the embryo takes about five days to enter the womb following fertilization, where it implants. On this day, the uterine lining is very receptive. As a result, blastocyst transfer is a more physiological procedure.
- Certain couples need pre-implantation genetic screening or pre-implantation genetic diagnosis. Because embryo biopsy is indicated to be done in the blastocyst stage instead of on Day 2/3 embryos, blastocyst culture is required for them.
Blastocyst transfer’s drawbacks
- There may be no drawback to day 5 blastocyst transfer if the IVF facility is skilled at blastocyst culture and has high-quality control in the laboratory.
- Nevertheless, if the culture environment isn’t ideal, embryo development will be delayed, and in certain situations, the embryonic arrest will occur.
- As a result, if the culture system and laboratory quality control are uneven, extended culture to day 5 will not yield good results.
- Day 3 transfers will be more successful in such protocols, as they will return embryos early, before they are overly “stressed” by the poor culture environment.
- Another disadvantage is that some clinics charge a higher fee for day 5 transfers.
Success rate of blastocyst transfer
According to the study, the rate of success of blastocyst transfer is 43.4 percent per blastocyst transfer based on the clinical pregnancy rate. During blastocyst transfer, just a few embryos are delivered to the uterus. Multiple pregnancies are less likely as a result of this, and the success rate rises even more. As a result, just one or two embryos are implanted into the uterus. If two embryos are transferred, 25 percent of the time, multiple pregnancies occur as both embryos begin to grow.
Get to know more about IVF success rates with blastocyst transfer
Who should go for blastocyst transfer?
- Couples that don’t want their extra embryos to be frozen.
- Those that want to get conceived without having to worry about many pregnancies.
- Couples who have been unable to conceive after transferring high-quality cleaved embryos on a regular basis.
Are you uncertain how much IVF in India costs?
When it comes to picking a fertility clinic, price comparisons are crucial, but you should also evaluate their success rates. If an IVF clinic has a rather low price, but their success rates are poor and numerous cycles may be required, it is not worth it to go with the cheaper clinic. When a doctor suggests IVF therapy, you may have a lot of questions. When you add in the financial hardship it causes for the majority of people, it’s easy to feel overwhelmed. For the vast majority of families, the cost of IVF is the most significant impediment to treatment.
The blastocyst culture method allows for healthier and genetically viable embryos to be selected. Although reaching the blastocyst stage does not ensure chromosomal normalcy, most embryos that do not develop further in prolonged culture show numerous aneuploidies. By extending the culture period to day 5, chromosomally competent embryos may be capable of developing to the blastocyst stage, allowing for the selection of embryos with the ability to develop further under embryonic genomic control. This method also allows the embryo stage to be more physiologically synchronized with the endometrium. As a result, transferring human blastocysts in IVF should boost the implantation rate and allow for the transfer of fewer, but higher-quality embryos, preserving the high pregnancy rate while reducing the incidence of high-order multiple gestations.